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KMID : 1143120200100020013
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Asia Pacific Allergy
2020 Volume.10 No. 2 p.13 ~ p.13
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Three cases of severe adolescent asthma treated with mepolizumab: lung function trajectories
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Hoshi Miyuki
Matsunaga Mayumi
Nogami Kazutaka
Hamada Kana
Kobori Taiga
Kainuma Keigo
Nagao Mizuho
Fujisawa Takao
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Abstract
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Real-world experience with mepolizumab for pediatric asthma is still limited. We report 3 patients who were treated with mepolizumab for severe adolescent asthma. Two patients, a 12-year-old boy and a 14-year-old girl, responded well to mepolizumab and showed apparent improvement in lung function from a downward trend over time before treatment. The third patient, a 16-year-old boy, whose treatment was switched from omalizumab to mepolizumab, did not have satisfactory response. The 2 successful cases had eosinophil counts of 440 and 371/μL and multiple comorbid allergic diseases including food allergies. The clinical benefit to them included elimination of both exacerbation and exercise-induced asthma. Interestingly, the boy's food-induced gastrointestinal symptoms disappeared following start of mepolizumab treatment.
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KEYWORD
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Severe asthma, Adolescent, Mepolizumab, Interleukin-5, Eosinophilic inflammation, Eosinophil count
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